QSAR studies on Withanolide analogs for anticancer activity
نویسندگان
چکیده
منابع مشابه
Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer
Withanolides are a group of pharmacologically active compounds present in most prodigal amounts in roots and leaves of Withania somnifera (Indian ginseng), one of the most important medicinal plants of Indian traditional practice of medicine. Withanolides are steroidal lactones (highly oxygenated C-28 phytochemicals) and have been reported to exhibit immunomodulatory, anticancer and other activ...
متن کاملXanthenones: calixarenes-catalyzed syntheses, anticancer activity and QSAR studies.
An efficient method is proposed for obtaining tetrahydrobenzo[a]xanthene-11-ones and tetrahydro-[1,3]-dioxolo[4,5-b]xanthen-9-ones. The method is based on the use of p-sulfonic acid calix[n]arenes as catalysts under solvent-free conditions. The antiproliferative activity of fifty-nine xanthenones against six human cancer cells was studied. The capacity of all compounds to inhibit cancer cell gr...
متن کاملQSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα
Due to the high mortality rate in India, the identification of novel molecules is important in the development of novel and potent anticancer drugs. Xanthones are natural constituents of plants in the families Bonnetiaceae and Clusiaceae, and comprise oxygenated heterocycles with a variety of biological activities along with an anticancer effect. To explore the anticancer compounds from xanthon...
متن کاملAnticancer activity of methyl-substituted oxaliplatin analogs.
Oxaliplatin is successfully used in systemic cancer therapy. However, resistance development and severe adverse effects are limiting factors for curative cancer treatment with oxaliplatin. The purpose of this study was to comparatively investigate in vitro and in vivo anticancer properties as well as the adverse effects of two methyl-substituted enantiomerically pure oxaliplatin analogs [[(1R,2...
متن کاملClassification of High-Activity Tiagabine Analogs by Binary QSAR Modeling
Termination of GABA-ergic signaling requires fast uptake of the neurotransmitter by highly selective transporter proteins. Four subtypes of sodiumand chloride-dependent GABA transporters exist, GAT-1 being the most prominent one in the brain. The only marketed drug targeting this transporter system is the anticonvulsant tiagabine. It is highly GAT-1 selective, consisting of R-nipecotic acid as ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Precedings
سال: 2011
ISSN: 1756-0357
DOI: 10.1038/npre.2011.6617